Changes of the blood plasma content of some factors of apoptosis and a soluble form of the factor of the receptor of the stem cells in patients with different types of vegetovascular dystonia

Abstract

It has been established that the blood content of protein P53 diminishes by 27 %, the blood level of sTRAIL increases by 22 %, sCD 117 by 44% in patients with vegeto-vascular dystonia of the hypertonic type that is accompanied with an increase of the activity of caspase-1, however, the activity of caspases-3 and – 8, as well as the blood content of TNF-α do not change. With vegeto-vascular dystonia of the hypotonic type the concentration of blood plasma protein P53, TNF-α and sTRAIL and the activity of caspases-1,-3,-8 correspond to the control values against a background of an almost twofold increase of the plasma sCD 117 level. A considerable elevation of the blood content of type II apoptotic factors is characteristic of the mixed type of vegeto-vascular dystonia: the level of protein p53 increases 2,4 times, TNF-α – 1,9 times, sTRAIL – 2,3 times that is accompanied with an increased activity of caspase-1 – 4,1 times, caspase-3 – 3,3 times, caspase-8 – 3,8 times and an increase of the plasma concentration of sCD 117 – 3,5 times.