Peculiarities of the carbohydrate metabolism in patients with latent autoimmune diabetes in adults depending on the level of autoimmunity

Abstract

The presence of specific autoantibodies is the basis for differential diagnosis and prediction of type 1 diabetes mellitus (T1DM), which since 2021 includes latent autoimmune diabetes in adults (LADA), as well as predicting its occurrence in people at increased risk of the disease to detect it in the preclinical period. It is believed that autoantibodies appear 7 or more years before the onset of the diabetes (DM) and are detected in the onset of T1DM with a frequency of 50 to 90%, as opposed to 1% in the general population. Moreover, the titer of these antibodies determines the course of the disease and helps to choose the right treatment tactics.