Experimental study of the kidney functions changes after pharmacological activation of potassium channels

Abstract

Adenosine triphosphate-sensitive potassium (KATP) channels of cell membranes play a special role in the mechanisms of restoration of disturbed oxygen homeostasis of the body. Their opening in response to a decrease in the intracellular ATP pool stabilizes energy processes, activates physiological reactions to hypoxia. The unique biological ability of KATP channels determines their research as targets for pharmacotherapy of multiorgan dysfunctions caused by hypoxia. Among the openers of KATP channels is Flocalin, which due to the presence of a fluorinated radical has powerful cardioprotective and vasodilating properties. Taking into account the presence of cardiorenal functional interconnections, it is logical to assume renal effects of Flocalin.