Lead acetate eefect on the state of lipid peroxidation and oxidative modification of proteins in the blood and liver of adult rats with different types of acetylation

Abstract

The growing anthropogenic load on environmental objects in the form of compounds of a chemical, physical and biological nature is quite serious. Among man-made chemical pollutants, lead and its compounds occupy a special place, which are characterized by high toxicity and a high ability to accumulate both in ecosystems and in human and animal bodies. There is an opinion that variations in the response of different individuals to environmental factors may be related to the features of the genotype to the genetically programmed system of biotransformation, degradation and removal of xenobiotics. However, the role of individual genetic predisposition as a cause of the body's sensitivity to the influence of toxic compounds, in particular heavy metals, has not been sufficiently studied to date. Therefore, the study of the toxic effect of lead acetate depending on the rate of acetylation is an urgent task, the solution of which will allow us to determine possible markers of the body's susceptibility to the action of this compound.