Effect of glutathione on oxidant-antioxidant system in hepatocytes under the conditions of experimental nephropathy

Abstract

In diseases of the kidneys and liver, a violation of oxidant-antioxidant protection leads to the accumulation of reactive oxygen species, activation of the free radical cascade, and peroxidation of lipids and proteins. The alteration of oxidant/antioxidant balance affects metabolism-related organelles, leading to phospholipid membrane damage and depletion of the body's antioxidant reserve. An important role in maintaining intracellular homeostasis is played by thiol-mediated redox control that can be provided by the most famous natural antioxidant, glutathione.