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dc.contributor.authorKoval, Halyna-
dc.contributor.authorOlenovych, Olha-
dc.date.accessioned2012-06-11T12:59:42Z-
dc.date.available2012-06-11T12:59:42Z-
dc.date.issued2011-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/1736-
dc.description.abstractWith the aim to define the role of lymphocyte apoptosis in the mechanisms of T-cell deficiency in patients with chronic obstructive pulmonary disease (COPD) accompanied by the disturbances of intestinal microbiocynosis, the investigation of caspases activity in lysate of lymphocytes was conducted. III degree of dysbiosis was found to be followed by the reduction of CD3+- and CD8+-cells number, and in patients with IV degree of intestinal microbiocynosis the level of lymphocytes of CD3+, CD4+, CD8+ phenotypes decreased in the peripheral blood, followed by the inhibition of phytohaemagglutinin (PHA) induced lymphocyte blast transformation. The activity of caspase-8, caspase-3 and caspase-1 in lymphocyte lysate of patients with COPD was of high rates in dysbiosis of III and IV degree.ru_RU
dc.publisherPharmacologyonlineru_RU
dc.subjectchronic obstructive pulmonary diseaseru_RU
dc.subjectdysbiosisru_RU
dc.subjectlymphocytesru_RU
dc.subjectapoptosisru_RU
dc.subjectimmune deficiencyru_RU
dc.subjectхронічне обструктивне захворювання легеньru_RU
dc.subjectдисбіозru_RU
dc.subjectлімфоцитиru_RU
dc.subjectапоптозru_RU
dc.subjectімунодефіцитru_RU
dc.subjectхроническая обструктивная болезнь легкихru_RU
dc.subjectдисбиозru_RU
dc.subjectлимфоцитыru_RU
dc.subjectапоптозru_RU
dc.subjectиммунодефицитru_RU
dc.titleCaspase-8 and caspase-3 activity in lymphocyte lysate of patients with chronic obstructive pulmonary disease and intestinal dysbiosisru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра клінічної імунології, алергології та ендокринології

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