SEVERAL PATHOGENETIC ASPECTS OF CARDIOVASCULAR DISORDERS IN NEWBORN WITH HYPOXIC DAMAGES

Abstract

The article is devoted to the establishment of the pathogenesis links of cardiovascular system hypoxic lesions in the early neonatal period by means of multi – factor correlation analysis of the investigation results of additional paraclinical methods. Namely: indicators of the biochemical spectrum of a blood, a complex free radical oxidation indices of the system and the systems of the organism antioxidant protection. The degree of severity of the detected changes from the cardiovascular system has a direct correlation with the severity of the newborn general condition under circumstances of perinatal pathology. It has been shown that the basis of myocardial damages of hypoxic genesis in newborns is cellular energy deficiency, metabolic disturbances, and links imbalance of the prooxidant and antioxidant systems of the organism, which leads to a decrease in functional activity and damage to cardiomyocytes, which is confirmed by the results of multi – factor correlation analysis.