Distribution of morphological variants of calcium deposits in placenta of gravidas with iron-deficiency anemia

Abstract

Our research conducted an investigation of 164 observations of placental calcinosis, including 84 observations of gravidas with iron-deficiency anemia and 80 observational gravidities without anemia. Frequency analysis of different variants of calcium deposits in chorial placental tree showed that type II and type IV perivillous fibrin deposits strongly dominated in gravidas with iron-deficiency anemia (over 90% and 80% placentas respectively). There were also deposits found in type III perivillous fibrin (about 45% of cases). These indices significantly exceeded the values of the frequency of women whose anemia had not been recorded during gravidity. Other variants of calcium deposits in iron-deficiency anemia occurred much more rarely. It should be mentioned, though, that in cases accompanied by gravidas with iron-deficiency anemia in comparison with observations of gravidas without anemia small granular deposits were more commonly found in the placental plasmodium of the chorial villi. Frequency analysis of different options of calcium deposits in the basal plate of the placenta showed that the observations of gravidas with iron-deficiency anemia as well as the observations of those without anemia dominated by calcium deposits in fibrin of all four types (type IV slightly smaller compared to other types). However, it should be pointed out that type II and type IV fibrin deposits were more frequently found in gravidas with iron-deficiency anemia compared with the observations without anemia (P <0,05).