Some pathogenic aspects of intestinal sutures insufficiency

Abstract

The changes of indices of proteolysis, fibrinolysis and lipid peroxidation in the sutured tissues of bowel were researched on the model of intestinal sutures insufficiency. It was established that the disturbances of primary biological leak resistance (12-24 hours) caused by excessive activation of tissues fibrinolysis, and the disturbances of regeneration of sutured tissues (24-72 hours) induced by prompt and continued activation of tissues proteolysis and lipid peroxidation associated with depletion of antioxidants, are a basis of progressing intestinal sutures insufficiency.