EFFECT OF THE DERIVATIVE OF 2-BENZAMIDO-2-(2-OXOINDOLIN-3-ILIDEN) ACETIC ACID ON THE ACTIVITY OF FREE-RADICAL PROCESSES IN TRAUMATIC BRAIN INJURY

Abstract

In experiments on adult laboratory rats investigated the effect of the derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid under the symbol ZNM the activity of the lipid and protein peroxidation and antioxidant system in blood plasma and brain, as well as the activity of the enzyme succinate energy metabolism in the brain with a closed traumatic brain injury (TBI) of moderate severity with the reference drug mexidol. It was established that ZNM not significantly inferior to the action mexidol with TBI and cerebroprotective on antioxidant properties, helping to normalize the prooxidant-antioxidant balance in the blood plasma and brain of rats, as well as improving the energy metabolism in the cells of the central nervous system.