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dc.contributor.authorLenga, E.L.-
dc.contributor.authorZamorsky, I.I.-
dc.contributor.authorBukataru, Yu.S.-
dc.contributor.authorKolisnyk, S.V.-
dc.contributor.authorAltukhov, O.O.-
dc.date.accessioned2016-10-10T09:36:53Z-
dc.date.available2016-10-10T09:36:53Z-
dc.date.issued2016-
dc.identifier.issn1562-7241-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/11666-
dc.description.abstractThe results of screening of 2-(benzoyilamino)(1-R-2-oxoindolin-3-ylidene)acetic acid derivatives on the antihypoxic activity are presented in the article. It has been determined that under the conditions of acute hypоbaric hypoxia compounds 4, 14 and 15 have shown the increase of the integral index of the antihypoxic activity of substances – the overall lifetime of animals at the “high-altitude plateau”. However, the mortality rate of animals reached 20% for compound 4, and it signifi cantly exceeded the control data. At the same time, compound 14 by its antihypoxic activity signifi cantly increased the overall lifetime of animals by 150% compared to the control data, but its effect was signifi cantly weaker than the effect of the reference drug mexidol, which increased the lifetime of animals by 197% (p<0.05). For compound 15 the overall lifetime of animals increased by 186% compared to the control data (p<0.05) and did not differ signifi cantly from that of the reference drug. The data obtained indicate that most of the substances studied – derivatives of 2-(benzoyilamino)(1-R-2-oxoindolin-3-ylidene)acetic acid – demonstrate certain antihypoxic properties, as well as derivatives of 2-(2-oxoindolin-3-ylidene)acetic acid previously researched. Moreover, only compound 15 corresponds to the antihypoxic effi cacy of the reference drug, and by the index of recovery of the animals’ physical activity after their staying at the “high-altitude plateau” (the posture recovery time) it exceeds the effect of the antihypoxant drug mexidol.ru_RU
dc.language.isoenru_RU
dc.publisherВІСНИК ФАРМАЦІЇru_RU
dc.relation.ispartofseries1(85);-
dc.subjectantihypoxantsru_RU
dc.subjecthypobaric hypoxiaru_RU
dc.subjectmexidolru_RU
dc.subjectderivatives of 2-(benzoyilamino)(1-R-2-oxoindolin- 3-ylidene)acetic acidru_RU
dc.titleSCREENING OF DERIVATIVES OF 2-(BENZOYILAMINO) (1-R-2-OXOINDOLIN-3-YLIDENE)ACETIC ACID UNDER THE CONDITIONS OF ACUTE HYPOBARIC HYPOXIAru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра біоорганічної і біологічної хімії та клінічної біохімії

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